MicroChemEco Lab - Synthesis and evaluation of a tag-free photoactive

Journal article

R. Dandela, R. Mashiach, Raju Adepu, R. Gregor, M. Athamna, Efrat Zecharia, Orna Ernst, T. Zor, M. Meijler
Chemical Communications, 2017

Semantic Scholar DOI PubMed

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APA Click to copy
Dandela, R., Mashiach, R., Adepu, R., Gregor, R., Athamna, M., Zecharia, E., … Meijler, M. (2017). Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages. Chemical Communications.

Chicago/Turabian Click to copy
Dandela, R., R. Mashiach, Raju Adepu, R. Gregor, M. Athamna, Efrat Zecharia, Orna Ernst, T. Zor, and M. Meijler. “Synthesis and Evaluation of a Tag-Free Photoactive Phospho-Ceramide Analogue-1 (PCERA-1) Probe to Study Immunomodulation in Macrophages.” Chemical Communications (2017).

MLA Click to copy
Dandela, R., et al. “Synthesis and Evaluation of a Tag-Free Photoactive Phospho-Ceramide Analogue-1 (PCERA-1) Probe to Study Immunomodulation in Macrophages.” Chemical Communications, 2017.

BibTeX Click to copy

@article{r2017a,
  title = {Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages.},
  year = {2017},
  journal = {Chemical Communications},
  author = {Dandela, R. and Mashiach, R. and Adepu, Raju and Gregor, R. and Athamna, M. and Zecharia, Efrat and Ernst, Orna and Zor, T. and Meijler, M.}
}

Abstract

Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.